Malaria which occurs due to Plasmodium parasites has been in news once again when results of an early-stage clinical trial published in August 8 in the Journal of Science. The results revealed that an investigational malaria vaccine titled PfSPZ Vaccine has been found safe to generate an immune system response and it offer protelaria infection in healthy adults. The vaccine has been developed by scientists at Sanaria Inc., of Rockville, Md.ction against ma
This news has generated a ray of hope in the minds of the people, as currently there is no vaccine to prevent this deadly disease for spreading its wings. According to World Health Organization, Malaria has killed over 660,00 people annually the majority of them children, however, it has affected more than 200m people annually. Symptoms of malaria are almost similar like that of flu viz., fever, chills, and flu-like illness.
Plasmodium vivax and P. ovale are the malaria species which infect humans and can develop hidden liver stages which can reactivate after symptomless intervals of two to four years. Pregnant women have been found with an increased susceptibility to Plasmodium flaciparum malaria.
How malaria spread in other parts of the body?
You may perhaps aware that malaria occurs in humans by the bite of an infected mosquito. After the bite, infectious malaria parasites in the immature, sporozoite stage of their life cycle make their way to the liver, where they multiply and spread through the bloodstream, here the symptoms of malaria starts developing. Did you
know that malaria disease can be categorized as uncomplicated or severed i.e. complicated? Generally malaria is curable disease if diagnosed and treated promptly and correctly.
Under uncomplicated malaria the attack lasts 6 to 10 hours and consists of a cold stage i.e. sensation of cold and shivering. A hot stage which includes fever, headaches, vomiting and seizures in young children and finally sweating occurs and an infected person feel tired and temperature return to normal.
Typically, this attack occurs every second day with the “tertian” parasites called p. faclciparum, p. vivax and p. ovale and on third day the attack occurs with the “quartan” parasite (p. malariae).
Outcome of the present study –
The researchers came to know that higher dosages of PfSPZ Vaccine can do wonder in controlling the malaria infection. During the study only three persons out of 15 participants who received higher dosages of the vaccine became infected as compared to 16 to 17 participants in the lower dosage group who also become infected. Those 12 participants who did not received any vaccine were also got infected. According to Robert A. Seder, M.D., chief of the Cellular Immunology Section of the NIAID Vaccine Research Center and principal investigator of the trial revealed that the results of the vaccine are promising and has forward its first step in generating high-level protection against malaria, further research will continue to focus on other areas.